Biodegradation Mechanisms of PLGA-Microparticles. The two main mechanisms that drive drug release from PLGA microspheres are diffusion and degradation/erosion (Kamaly et al., 2016). For PLGA (50:50) particles, drug release occurs in two phases. S. Schwendeman, K.Hirota, A. Doty, Y. Wang, S. Choi, and W. Qu, Mechanistic evaluation of in vitro and in vivo release from PLGA microspheres employing a cage model. A novel and simple preparative method for uniform-sized PLGA microspheres: Preliminary application in antitubercular drug delivery. For example, microspheres prepared using 70 KD PLGA have a lag phase of approximately 45 days, during which a limited amount of drug is released . Drug Design, Discovery and Therapy; Earth and Environmental Sciences; Energy and Fuels; Engineering and Technology; Food Sciences and Nutrition; Genetics; Healthcare; Life Sciences; Material Sciences; Medicine; Mathematics and Statistics; Nanoscience; Physics and Astronomy; Social Sciences; Technology Transfer and Entrepreneurship; Exhibit Schedule; Health Care Industry Resources Furthermore, they can also ... PLGA microspheres prepared by freeze-drying [31]. 20 days. evaluated Dex-encapsulated PLGA microsphere and found that the sites with Dex-releasing microsphere had thin deposits of fibrous tissue and reduced the number of immune cells around the implants, indicating a suppression of … Bioadhesive Microspheres as Systems Able to Enhance Pulmonary Drug Delivery 29 1.8. Microspheres have been proved to be a suitable bridge to scale the distance over to formulate an effective dosage form, to simulate controlled drug … AIM OF THE WORK 49 4. CHITOSAN AND PLGA: GENERAL INFORMATIONS 35 2.1. However, PLGA is highly hydrophobic and lacks functional ligands for cell attachment. Chitosan and Chitosan Microspheres as Controlled Delivery System 36 2.2. DBZ-loaded PLGA microspheres with a size range of 50–150 μm were prepared as a DBZ delivery system using an emulsion/solvent evaporation technique. Such systems offer numerous advantages over traditional methods of drug delivery, including tailoring of drug release rates, protection of fragile drugs and increased patient comfort and compliance. As a service to our customers we are providing this early version of the manuscript. Mi FL(1), Shyu SS, Lin YM, Wu YB, Peng CK, Tsai YH. Microspheres for Inhalation 30 2. 7, 3459–3468 (2011).Crossref, Medline, Google Scholar; 98 Parveen S, Sahoo S. Long circulating chitosan/PEG blended PLGA nanoparticle for tumor drug delivery. Open Access Dissertations. CHITOSAN AND PLGA: GENERAL INFORMATIONS 35 2.1. PLGA microspheres have been extensively studied for controlled-release drug delivery [1-4] mainly because of the biodegradable and bioabsorbable qualities that allow for the passive degradation of the polymer in aqueous environments such as living tissues and for the PLGA and PLGA Microspheres as Controlled Delivery System 40 3. These biodegradable microspheres were prepared by directly blending chitin with different contents of poly(D,L-lactide-co-glycolide 50:50) (PLGA 50/50) in dimethylacetamide-lithium chloride solution, and following it by coagulating in water via wet phase inversion. The drugs were delivered by the PLGA-based microspheres to the yolk sac of zebrafish embryos, and a sustained drug release was observed to examine the anti-angiogenesis and angiogenesis activities. Eur. Methods: The microspheres containing … J. Pharmacol. Au-tocatalysis is known to have a complex role in the dynamics of … The peak serum drug concentration of octreotide was reached in 30 min for all formulations followed by a decline after 6 h. Since the approval of Zoladex and Lupron Depot for the treatment of prostate cancer in 1989, the use of polylactide (PLA)/poly lactic-co-glycolic acid (PLGA)-based delivery systems has enabled the development of extended-release formulations that can reduce dosing frequency and minimize drug side effects. Other than pulmonary drug delivery, PLGA PMs have been employed as cell carriers for cartilage repairing and myocardial defects , , . The PLGA-based microspheres degraded in zebrafish, thereby verifying that these microspheres can be used as drug carriers in vivo to ensure good biocompatibility and biodegradation. Aug 21, 2018. For injectable PLA/PLGA-based drug products, the test product should be qualitatively (Q1) and quantitatively (Q2) the same as the RLD to be considered for approval in an Abbreviated New Drug Application (ANDA). 1 Differences in PLA/PLGA characteristics can vastly alter the drug release mechanism and release rate. 1.7. Chitin/PLGA blend microspheres as a biodegradable drug delivery system: a new delivery system for protein. Plain PLGA microspheres and nanoparticles can be used in drug delivery research and formulation as control agents or can be used to test system compatibility before loading an API into the carrier. Acta Biomat. Bioadhesive Microspheres as Systems Able to Enhance Pulmonary Drug Delivery 29 1.8. 14th European Symposium on Controlled Drug Delivery, 2016. The purpose of this research was to develop polylactic-co-glycolic acid (PLGA) microspheres for continuous delivery of dexamethasone for over a 1-month period, in an effort to suppress the acute and chronic inflammatory reactions to implants such as biosensors, which interfere with their functionality. Fluorescent nanoparticles and microspheres can be used in imaging and diagnostic applications for the detection of binding events or signal enhancement. ABSTRACT: Microspheres play a very important role as particulate drug delivery system because of their small size and other efficient properties. The purpose of this study was to investigate the feasibility of poly lactic/glycolic acid (PLGA) as a Microspheres as Controlled Delivery Systems 26 1.7. Preparation technique of PLGA microsphere PLGA in the form of microspheres is widely used for encapsulation of a broad category of therapeutic agents. Keywords Etoposide, in vitro drug release, physicochemical characteristics and micromeritics properties, PLGA microspheres, pulmonary drug delivery History Received 22 July 2013 These drug delivery systems (DDS), including micro and nanoparticles, have the potential to modify their surface properties and improve interactions with biological materials. Poly[lactic-co-(glycolic acid)] (PLGA) has been widely studied in both drug delivery systems and tissue engineering due to its good biocompatibility and adjustable degradation rate , . Zhiqiang Liu Department of Bio-diagnosis, Beijing Institute of Basic Medical Sciences, 27 Taiping Road, Haidian District, Beijing 100850, China. The current aim of this review is … Abstract: Poly (lactic-co-glycolic) acid (PLGA) microspheres have been extensively studied for controlled drug delivery, and more than a dozen PLGA formulations are currently on the market. PLGA microspheres are widely studied for controlled release drug delivery applications, and many models have been proposed to describe PLGA degradation and erosion and drug release from the bulk polymer. PLGA has excellent biodegradability and biocompatibility and is generally recognized as safe by international regulatory agencies including the United States Food and Drug Administration and the European … In this work, bee wax microspheres as drug delivery vehicles prepared via the chemical method and the size of the microspheres can be controlled by numerous process parameters such as agitation speed, wax/solvent ratio, agitation time and temperature.
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